Mast cell activation may explain many cases of chemical intolerance

Abstract Background This paper explores the relationship between chemical intolerance (CI) and mast cell activation syndrome (MCAS). Worldwide observations provide evidence for a two-stage disease process called toxicant-induced loss of tolerance (TILT) as mechanism CI. TILT is initiated by major exposure event or series lower-level exposures. Subsequently, affected individuals report that common inhalants, foods, drugs (i.e., various xenobiotics) trigger multi-system symptoms. Purpose To determine whether MCAS provides plausible biological CI/TILT. Methods Using validated Quick Environmental Exposure Sensitivity Inventory (QEESI), we compared patients diagnosed with ( n = 147) to who reported intolerances (CI/TILT) following exposures 345) healthy controls 76). ANOVA, QEESI scores across groups. Clinical patient group were used predict CI status using logistic regression. Results More than half (59%) met criteria A regression model illustrates likelihood having increased, their CI/TILT similarly near-perfect correspondence at high ends clinical scores. Symptom patterns nearly identical Discussion We present data suggesting xenobiotic cells may underlie The strikingly similar symptom suggest xenobiotics disrupt cells, leading either both these challenging conditions. Faced suffering from complex illness affecting multiple organ systems fluctuating inflammatory, allergic, dystrophic symptoms, clinicians can now ask themselves two questions: (1) Could be root problems? (2) environmental driving MC mediator release? Increasing our understanding connection MCs has potential expose new link illness, offering opportunities improving individual public health. Conclusion close supports xenobiotic-driven release MCAS) unifying CI/TILT, profound implications medicine, health, regulatory toxicology.